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Jane Jetson(เจน เจ็ทสัน): อายุ32 ปี เป็นภรรยาของจอร์จ, ชอบไปช็อปปิ้งเป็นชีวิตจิตใจ
Elroy Jetson(เอลลอย เจ็ทสัน):อายุ 6 ปี and a half (self-reported in the first episode), is the younger of the two children in the Jetson family. He is highly intelligent and an expert in all space sciences. Elroy attends Little Dipper School where he studies space history, astrophysics and star geometry. He is a mild mannered and good child.
Rosie: age 45, is the Jetsons' household robot. She's an outdated model but the Jetsons love her and would never trade her for a newer model. Rosie does all the household chores and some of the parenting. She is a strong disciplinarian and occasionally dispenses advice to the family.
Astro the Dog: age unknown, Originally called Tralfaz. Astro is the Jetsons' family dog. Prior to being a Jetson he belonged to the fabulously rich Mr. Gottrockets. Astro is George's best friend, and is able to speak in a rough sounding English, somewhat like Scooby-Doo, whom Astro "pre-dates" in the "real world" by seven years.
Besides the increased presence of Rosie and the addition of Orbitty, further differences between the 1960s version and 1980s version include the following:
- The original 1960s episodes are distinguished by 1960s style animation, music, and references (similar to The Flintstones and other Hanna-Barbera shows of that period).
- The cast members have a slightly softer vocal tone in their 1960s-era performances, since they were about twenty years younger when originally working on the series.
- Whereas the 1960s stories were basically 1950s sitcom plots in a futuristic setting, the 1980s stories delved into fantastic, sci-fi cartoon territory.
- The opening credits of the 1980s version contain a rerecorded version of the original Jetsons theme song, which features the use of synthesized drums to create percussion typical of 1980s music.
- The 1980s version has a smoother look and cleaner sound, primarily due to Hanna-Barbera's switch to computer aided animation techniques at the time.
- While episodes made in the 1960s referenced rockets and other "space age" theme devices, reflective of the real-life U.S. space program which fascinated America, the 1980s episodes leaned more towards how computers would influence life in the future.
- Jane's lipstick in 1980s version is darker red.
- Orbity is introduced in 1980s version
- In the 1960s version, the characters of Rosie and Astro never appeared in the same episode.